Eleanor and Lou Gehrig MDA/ALS Research Center Projects Funded by MDA's Wings Over Wall Street® 2003 Investigators Affiliation Topic Total Funding Hiroshi Mitsumoto, M.D. Ruth Ottman, Ph.D. ALS Center, and Sergievsky Center, CU Epidemiology of Genetic and Environmental Interactions $72,000 Paul Gordon, M.D. ALS Center, CU Clinical Trial of Glatiramer Acetate in ALS $100,000 Hiroshi Mitsumoto, M.D. Andreas Kottman, Ph.D. ALS Center and Columbia Genome Center, CU Genetic Basis of Variable Phenotypic Expression in ALS $70,000 Paul Gordon, M.D. Michio Hirano, M.D., Ali Naini, Ph.D. ALS Center, and Houston-Merritt Neuromuscular Research Center, CU Linkage Study to identify the novel modifier genes in familial ALS with SOD1 mutation $25,828 Thomas Jessell, PhD Center for Neurobiology and Behavior, CU 1) Characterization of Motor Neuron Progenitor Cells; 2) directed differentiation of embryonic stem cells into Motor Neurons; and 3) the physiology and function ES cell-derived motor neurons in mammalian spinal cord $50,000 Serge Perzedborksi, MD, PhD, Thomas Jessell, PhD ALS Center, Neurology and Pathology,Center for Neurobiology and Behavior, CU Role of endoplasmic reticulum (ER) stress in ALS 2) Cell replacement strategies using stem cells in SOD1 transgenic rodents $75,000 William Dauer, MD Neurology, CU Generating and Characterizing an Inducible Model of ALS $50,000 Andreas H. Kottmann, PhD Columbia Genome Center, CU Function of wfs1 in the context of cranial and spinal motor neuron maintenance in mouse and in organotypic cultures $70,000 TOTAL $512,828