The Robert Packard Center for ALS Research at Johns Hopkins Projects Funded by 2005 MDA's Wings Over Wall Street®®
Investigator	Project	Cost	Goal
Philip C. Wong, PhD	Generation & Characterization of Wildtype & Mutant (G59S)pa50glued Dynactin Transgenic Mice	$217,011	To create a new mouse model to help determine whether axonal transport plays a critical role in mutant dynactin p150glued-linked ALS. These studies will not only have important mechanistic and therapeutic implications for familial ALS but potentially for sporadic ALS as well.
Valeria Culotta, PhD	The Role of Glutaredoxins in Misfolding of ALS SOD1	$67,910	To examine the ability of recombinant human GRX1 and GRX2 to reduce the disulfide of ALS mutant SOD1 in vitro. The reactivity of human GRXs towards the disulfide of ALS mutant SOD1 expressed in yeast will also be tested.
Ton Li, PhD	Generation & Characterization of Wildtype & Mutant Senetaxin Transgenic Mice	$204,385	To test the hypothesis that mutations in senataxin lead to a gain of a novel toxic function. To do this a mouse that overexpresses the human mutant and wildtype senataxin will be generated. Furthermore, since the dysfunction of the helicase of senataxin in ALS4 may also play an important role in motor neuron degradation, a senataxin knockout mouse will also be created in a separate experiment.